Sentence examples for that may destabilize from inspiring English sources

Mutations that confer resistance to crizotinib [102] include several that may destabilize the intramolecular A-loop helix packing that is apparently part of the inactivation mechanism for ALK [103].

As observed above, important changes to the secondary structure of TM2 are also expected in the L90P mutation due to the introduction of Pro that may destabilize the helical conformation near the cytoplasmic mouth of the pore.

This is supported by the presence of a frameshift mutation in the exon 2 sequence of these genes that generates a premature STOP codon that may destabilize mRNA by nonsense-mediated mRNA decay (NMD), as has been shown for some other mRNA [27].

Under the compensatory model, substitutions that may destabilize protein structures or inhibit function could be compensated by a subsequent (or simultaneous) substitution at an adjacent site (Pollock et al. 1999).

Hypermethylation of promoter CpG islands with associated loss of gene expression, and hypomethylation of CpG-rich repetitive elements that may destabilize the genome are common events in most, if not all, epithelial cancers.

Our studies indicate that CA3 neurons are more vulnerable to HH than CA1 neurons, and that may destabilize the neural circuits in the hippocampus and thus cause memory dysfunction.

The seeming tranquility, however, belies deep-seated structural changes that may yet destabilize the monarchy.

This rupture of the epithelium integrity likely leads to changes of metabolite exchange between the retina and the choroid that may further destabilize photoreceptors after exposure to high levels of light.

We have a crane here that can pick that up, but we just want to make sure there's nobody else alive that we can detect with the dogs or devices, because in doing that you may destabilize the pile of rubble and fall further onto somebody.

Interestingly, stochastic simulations predict that TCDD may destabilize the plasma cell state, possibly leading to a reversal to the B cell phenotype.

"Behind these disturbing statistics are families facing personal and financial hardship and neighborhoods that may be destabilized by clusters of foreclosures," Mr. Bernanke said.