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Consequently, we next assessed the conjugation systems that lay downstream of beclin1 responsible for the lipidation of LC324, searching for the target protein(s) that are oxidized by H2O2, as they would likely mediate the inhibition of autophagy.
In tandem with this chemical genetic approach, have been approaches that have generated mutant receptors designed to determine the physiologically relevant signalling pathways that lay downstream of receptor activation.
For each human protein, a number of measures of its hierarchical position in the network were computed: in-degree and out-degree (number of upcoming and outgoing edges in the network, respectively), and the total number of proteins that lay downstream of the protein of interest (termed H).
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However difficult the transition, manufacturers can't afford to ignore the opportunities that lie downstream.
These methods can be used to identify genes that lie downstream of developmentally important transcription factors and genes that are expressed in specific tissues, processes, or stages of embryonic development.
The kind of pollution we found in China is likely to be present in every estuary that lies downstream from urban development or animal agriculture.
This is indicative of a block in division that lies downstream of FtsZ assembly.
Understanding the mechanisms by which β-arrestins activate signaling pathways like ERK1/2 is critical given the important biological responses that lie downstream of these pathways.
We next sought to identify the transcriptional target of FoxO3a that lies downstream of the Akt1 anti-apoptotic signaling in osteoblasts.
Bim, Bcl-2-interacting mediator of cell death, was shown to be a transcriptional target of FoxO3a that lies downstream of the Akt1 anti-apoptotic signaling in osteoblasts.
Consistent with this, immunoprecipitation studies reveal reduced tyrosine phosphorylation of several other signalling proteins that lie downstream of the FcRγ-chain in the GPVI signalling cascade, namely Syk, Btk and PLCγ2 (Fig 6C).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com