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Exact(14)
The paediatric population was excluded for one obvious reason, that is the difficulty to obtain the PEFR reading.
Degree of corroboration of a phylogenetic tree hypothesis is given by improbability of that goodness-of-fit — that is, the difficulty in explaining fit that good by other factors, including elements of chance, that make up our "background knowledge".
"Rather than altitude gain or temperature, it's the terrain that is the difficulty here," explained Jens Waechter, a German ultra-runner who lives in Ireland and placed second in the 2013 race.
That is the difficulty.
But that is the difficulty.
DR. SEIDL: That is the difficulty, Mr. President.
Similar(46)
No, it's the play itself that's the difficulty: it's at the same time daft and dazzling.
"That's the difficulty of that play".
That's the difficulty we have here.
Maybe that's the difficulty you're prepared to accept.
That's the difficulty and also the insurance against mistakes.
More suggestions(15)
that is the obstacle
that is the predicament
that is the dilemma
that is the challenge
that is the time
that is the challenges
that is the issues
that incorporates the difficulty
that is the challenging
that is the constraints
that is the combination
that is the advantage
that is the reason
that is the origin
that is the thesis
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com