"From founding this company to guiding its growth into a trusted global brand that is indispensible to millions of people, I have always sought to do what is best for our franchise," said Jerry Yang.
ZNF143 was previously reported as one of the several transcription factors responsible for maintaining the normal transcription levels of the mammalian mitochondrial transcription factor A (TFAM), a nuclear-encoded mitochondrial transcription factor that is indispensible for the expression of key mitochondrial-encoded genes and for the replication of mitochondrial DNA.
Recently, studies into Lactobacillus rhamnosus have shown that this bacterium contains pili that are indispensible for interactions with human mucus [31].
This interpretation is strengthened by life cell imaging experiments showing the importance of mitochondria in dendritic spines for the plasticity of synapses [50] and secondly by developmental gene expression studies of the whole cerebellum where parallel up-regulation was found for genes that are indispensible for synaptic activity and plasticity [51].
Phospholipids in cell membranes, actin and myosin in muscle cells, or collagen and hydroxyapatite in bones are chemical structures that are indispensible in the biology of a vertebrate and exist in all vertebrates.
The benzoquinone embelin acts as a weak mitochondrial uncoupler, and this prevents energy-intensive processes such as proliferation, migration, and capillary tube formation that are indispensible for neoangiogenesis during tumor growth and wound healing.
Polyamines are multifunctional polycations that are indispensible for cancer cell survival, influencing a range of biological processes including DNA synthesis and stability, replication, transcription and translation, ribosome biogenesis, and protein phosphorylation [152].
The public health community can contribute to the establishment of and participate in routine training programs and exercises that are indispensible components of preparedness and response to chemical incidents.
In S. aureus, the assembly of WTA polymers begins with two non-essential steps for cell viability, encoded in tarO and tarA, and continues with late-acting gene products that are indispensible upon initiation of polymer synthesis.
However, some of the biological effects of resveratrol are also observed at a very low concentration [ 26, 27], bringing forward the idea that resveratrol exerts its major effects on the intestinal tissue, affecting the rest of the body through secondary effects that are indispensible of the plasma levels reached by the compound [ 6].
One approach for the identification of new antibiotic targets for a particular bacterial pathogen is to identify non-redundant cellular functions or metabolic pathways that are indispensible for growth and/or survival of that organism; for example, key metabolic enzymes or cell wall synthesis proteins.
