Erh1 interacts with Mmi1 through an interface that is conserved in the human ERH protein.
The crystal structure of GSDMA3 showed an autoinhibited two-domain architecture that is conserved in the gasdermin family.
APC/CCdh1 targets Id2 for degradation through a destruction box motif (D box) that is conserved in Id1 and Id4.
Birve, A. et al. Su z 12, a novel Drosophila Polycomb group gene that is conserved in vertebrates and plants.
NPHP4 encodes a novel protein, nephroretinin, that is conserved in evolution for example, in the nematode Caenorhabditis elegans.
RNA silencing is a sequence-specific RNA degradation system that is conserved in a wide range of organisms.
We show that AvrXv4 recognition by resistant plants requires a functional protease catalytic core, the domain that is conserved in all of the putative YopJ-like cysteine proteases.
Sequence analysis revealed that the GCPs share five regions of sequence similarity and define a novel protein superfamily that is conserved in metazoans.
Our findings support the hypothesis that the KRAS-variant has a fundamental biological impact on normal cellular biology, that is conserved in these patients when they develop cancer.
Here, we examine the synaptic effects of an autism-associated neuroligin-4 substitution (called R704C), which mutates a cytoplasmic arginine residue that is conserved in all neuroligins.
Calcineurin is a serine-threonine specific Ca(2+ -calmodulin-activated protein phosphatase that is conserved from yeast to humans.
