Sentence examples for that ide from inspiring English sources
IDE knockout mice are both glucose-intolerant and hyperinsulinemic, supporting the concept that IDE is important in the maintenance of normal blood glucose and insulin levels [2].
This figure shows that IDE and SL0 have the lowest complexity.
Our findings show that IDE activity is driven by the dynamic equilibrium between Aβ monomers and higher ordered aggregates.
While screening brain cells for proteins that destroy b-amyloid, they discovered that IDE seemed to dispose of most naturally secreted b-amyloid.
We have previously reported (Grasso et al., Chem. Eur. J. 17 (2011) 2752 2762) that IDE activity toward Aβ peptides can be modulated by metal ions.
The data are "very encouraging," says Alzheimer's researcher Frank Laferla of the University of California, Irvine, but he remains unconvinced that IDE cleans out the bulk of b-amyloid.
Theoretically, studies on IDEs depend greatly on the type of interval-valued derivative, as different concepts of derivatives require that IDEs satisfy different conditions so as to ensure IDEs' solution existence and uniqueness.
We show that GSNO inhibits IDE-mediated degradation of two IDE substrates, insulin and Aβ, and that IDE-mediated regulation of the proteasome is inhibited.
In conclusion, we have clearly demonstrated that IDE-dependent cleavage of the non-amyloidogenic hAChE oligomerisation domain leads to a conformational switch to β-structure and liberates surface-active peptides that assemble into amyloid protofibrils and seed the aggregation of hetero-oligomers comprised of Aβ and CSR species.
It is with UNICEF's financial, material and technical support that IDE-Afrique carries out its activities in the area of community mobilization and offers care and support to children orphaned by AIDS and to other vulnerable children in the 18 Montagnes region.
This is further supported by the fact that the IDE mutant (IDE-E111Q) which is impaired for degradation of insulin, fails to induce a conformational change in gE.
