Sentence examples for that have been refractory from inspiring English sources

This novel method of gene silencing has substantial promise for elucidation of gene function in bacterial species that have been refractory to experimental introduction of exogenous DNA.

These methods may be broadly applicable to the production of biosynthetic enzymes from other natural product biosynthetic gene clusters, especially those that have been refractory to production in heterologous hosts despite standard expression optimization methods.

Domesticated crop species typically have very large, highly repetitive genomes that have been refractory to attempts to generate completed genome sequences.

Thus, among patients with early AKI, other organ failures on D3 that have been refractory to ICU treatment or have developed while in ICU, serve as predictors of adverse long-term outcome.

However, others have argued that the careful selection of a 'core' of genes that have been refractory to transfer may help solving (at least partly) this conundrum [ 3- 6].

Radiofrequency denervation is commonly used for the treatment of chronic facet joint pain that has been refractory to more conservative treatments, although the evidence supporting this treatment has been controversial.

As illustrated in our case, treatment of the Graves' disease did result in a significant improvement of thrombocytopenia that had been refractory to IVIg and steroid treatment.

A good example of that was the improvement of endothelial function following rituximab therapy in patients with RA that had been refractory to anti-TNF-alpha drugs [ 139, 140].

More recently it was shown that gene expression is altered in the mammary gland of parous mice and rats as compared with virgin animals [ 8]; similarly, rats that have been made refractory to mammary tumorigenesis by estrogen and progesterone treatments also exhibit differences in the mammary gland gene expression as compared with untreated rats [ 9].

Importantly, intracellular ATP is a requirement for merozoite invasion [31] [34] with erythrocytes that have been depleted of ATP being refractory to invasion.

In combination, these studies continue to highlight the enormous potential of EPiC chemotherapeutics for the treatment of brain tumours that, until recently, have been refractory to most available therapies.