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We expect that further functional and mechanistic studies of regulatory RNAs will reveal additional mechanisms of gene regulation.
We expect that further functional studies of the down-regulated genes in our common signature will reveal novel metastasis suppressor genes.
Interestingly, a majority of these motifs came from two categories, hypothetical proteins and proteins associated with phage-related functions, suggesting that further functional characterization will help better understand the epidemiological implications of such repeats in the genomics of X. fastidiosa strains.
This suggests that either the miRNA targets are highly over predicted or that further functional miRNA target enhancer motifs awaiting discovery.
However, it is clear that further functional experiment studies are needed to solve the question of the origin of circulating miRNAs.
According to the above-mentioned data, it is quite obvious that further functional analysis of the different TPI variants is mandatory for comprehending the molecular mechanisms underlying pathogenesis in TPI deficiency.
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Overall, the proposed RCT-based polymeric siRNA nanoflower formulation can provide a new platform technology that allows further functional modifications via an advanced annealing method for systemic cancer RNAi therapy.
Thus, real-time gamma power analysis may yield observations that provide further functional mapping hypotheses to be tested with ECS.
It is conceivable that the effect of AtVOZs on flowering could result from altered nucleocytoplasmic localization and consequently activity of some flowering-time transcripts, a possibility that requires further functional analyses.
Chiu and Wu [ 19] analyzed miRNA profiles derived from mouse bone marrow-derived macrophages and identified 431 miRNAs and 498 differentially expressed target genes that await further functional characterization.
By contrast, primary granule fusion with the plasma membrane instead leads to hyperexocytosis and potential reprogramming (3), a third fate that further emphasizes the functional plasticity of human neutrophils.
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