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Classical SAR based cellular optimization provided us with a PORCN inhibitor with nanomolar activity and excellent bioavailability that demonstrated efficacy in a Wnt-driven murine tumor model.
He was principal investigator of the trial on male circumcision for HIV prevention that demonstrated efficacy of circumcision for prevention of HIV, herpes virus and human papillomavirus in men.
The treatments investigated in the current study are two behavioral therapies that demonstrated efficacy in the management of chronic insomnia: stimulus control therapy and sleep restriction therapy [ 25].
Etoricoxib has demonstrated efficacy in many painful conditions, including a previous study that demonstrated efficacy in patients undergoing total knee or hip arthroplasty [ 11].
The Walter Reed Army Institute of Research WRAIRR) developed a DENV purified-inactivated vaccine (PIV) candidate that demonstrated efficacy in primates.
In 1995, an initiative that demonstrated efficacy in reducing health disparities among low-income minority women with an abnormal breast screening test in Harlem, New York, resulted in the launching of patient navigation programs nationwide [ 3, 4].
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But where are the studies that demonstrate efficacy?
No other SSRI and nonSSRI new antidepressant has two controlled trials that demonstrate efficacy.
This includes current information regarding agents that demonstrate efficacy, those that do not and those that can be used as standard controls.
Systemic corticosteroids are often prescribed empirically to treat diffuse lung disease associated with ABCA3 or SFTPC mutations by immunomodulation, but clinical trial data that demonstrates efficacy of this therapeutic strategy is lacking at this time.
In any animal model of human disease a positive control therapy that demonstrates efficacy in both the animal model and the human disease can validate the application of that animal model to the discovery of new therapeutics.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com