Want to remember that deleterious means "causing harm and damage"?
A troubling aspect of this range is that it has a "fat upper tail", implying that deleterious surprises are more likely than benign surprises.
We hypothesized that deleterious DNMs may play a role in cases of autism spectrum disorders (ASD) and schizophrenia (SCZ), two etiologically heterogeneous disorders with significantly reduced reproductive fitness.
The explanation for this is that deleterious alleles often tend to be recessive, so have no phenotypic effect when found in heterozygotes.
These results clearly demonstrated that deleterious interactions in Group III (interactions of Sa and Sb pollen sterility loci) have more pronounced effects on the pollen sterility of polyploid rice compared to other groups.
This is the first time that deleterious steric hindrance from long single-stranded regions adjacent to the electrode surface is reported for relatively short amplicons (less than 200 bp).
Measuring real-time oxygen consumption in siRNA-transfected INS-1E cells, we show that deleterious effects of palmitate on the glucose sensitivity of mitochondrial respiration and on the coupling efficiency of oxidative phosphorylation are independent of UCP2.
Recent reports have also shown that deleterious mutations at two 3'UTR 8-mer mononucleotide repeats destabilize the mRNAs in which these mutations occur [9], [10].
As dog breeders make breeding decisions based on many factors, it is unlikely that deleterious inbreeding would occur in a large diverse breed like the Labrador retriever.
Alternatively, because the two subunits have clearly different functions, it is possible that deleterious mutations in the catalytic core have more serious consequences for the animal.
Interestingly, the mRNA of the major gene, VtgAo1, is expressed 100 1000× higher than those of either the complete VtgAo2 or the phosvitinless form [98], suggesting that deleterious mutations have occurred in the cis-regulatory elements of the VtgAo2 genes.
