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This includes (i) intracellular messengers like cAMP and associated kinases, (ii) mitochondrial enzymes responsive to acute changes in biochemical ratios such acetyl-CoA/CoA and NADH/NAD+ ratios, (iii) hormones that recruit specific substrate receptors like Glut4, and/or (iv) transcription factors that could alters metabolic patterns and substrate utilization at multiple, programmatic levels.
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