Fifty years later, Oparin has suggested, in the first comprehensive scenario of the abiogenic origin of life (abiogenesis), that the primordial reducing atmosphere could have favoured the spontaneous formation of proteinaceous bodies that could aggregate into coacervates (protocells) [ 3, 4].
Originally documented as a cytosolic HIN200 family protein for binding dsDNA, AIM2 was recently identified as an inflammasome-inducing sensor that could aggregate with caspase 1 and ASC [ 200].
"I'd be surprised to come across a global bank that could aggregate its exposure to a counterparty on a single screen," says Andreas Andreades, the boss of Temenos, a company that provides software for banks.
It was the structure that could aggregate available information, systemize it in ways that were useful to all, and make it widely available.
"I was thinking," says Blake, "it would be nice if I had a machine that could aggregate all of the opinions on the internet; only it would filter out all the descriptions of music using words that are shit.
More modern tools — algorithms that could aggregate and weight polls, a sharper appreciation of the predictive value of demographics — made elections seem like long-term, tidal contests, and the daily theatre of spin and news cycles just a lot of noise.
Creating a feature that could aggregate content from the wider web would make sense: if Graph Search already lets you look in the wider web for content, why not an RSS feed to help aggregate that better?
As it became apparent that electricity was as invaluable of a commodity as gas, water and the telephone, utility companies and national electrical grids that could aggregate and distribute electricity on demand replaced the privately owned generators.
Pollutant concentrations were classified according to a common scale that could be aggregated to assess cumulative exposures to multiple pollutants within a subclass.
At the turning of the century, a multimolecular PTP model was proposed that included proteins of all mitochondrial compartments, as it was postulated that these could aggregate at "contact sites" between the outer and the inner membranes [37].
Another interesting observation was that the bacteria could aggregate on hyphae without interrupting hyphal growth, as shown in Fig. 2d.
