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Exact(45)
El-Deiry and coworkers used a high-throughput screen to identify small molecules that could activate p53 reporter activity, increase expression of p53 target genes such as p21(Waf1), DR5 and TRAIL, and induce apoptosis in p53-deficient colon cancer cells [ 35].
This refinement, which became known as quantitative structure-activity relationship, simplified the search for chemical structures that could activate or block various drug receptors.
Did selective culling disrupt badger social groupings and territories, causing the stress that could activate the disease and the movement that would ensure its spread?
He was unaware that his parcel was an explosive, which weighed about 20 pounds and was attached to a cellphone that could activate it, the officials said.
But most people cannot keep to a diet with a 30percentt cut in calories, so a drug that could activate the famine reflex might be highly desirable.
Today scientists are investigating pharmaceuticals that could activate dormant NSCs in case the areas where neurons are located become damaged.
Similar(15)
These results proved that ERα could activate the transcription activity of the Bmi1 core promoter.
Dual luciferase assay demonstrated that E2F-1 could activate PUMA promoter activity 9.3-fold.
14 Our study also validated that FMNL2 could activate the MAL/SRF transcriptional activity.
FBW7 has several substrates that are involved in mitosis that could potentially activate the SAC.
The more advanced receptor design incorporated additional endodomains that could simultaneously activate more than one signaling pathway.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com