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TCA drugs cocrystallized with LeuT were bound in the protein's extracellular vestibule, in a pocket just to the extracellular side of the four "external gate" residues that control entry into the S1 pocket.
Feedback regulation is one of the major characteristics of transcriptional activators that control entry into developmental pathways (for specific examples see [1]).
Thus, the decrease of Gdh2 activity is regulated by mechanisms that control entry into meiosis.
Thus, SCD proteins are enriched for roles revolving around the end of mitosis, from the mitotic networks that control entry into anaphase and telophase to the regulation and formation of the contractile ring during cytokinesis to pathways that control cytokinesis and telophase completion.
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Wee1 and Cdc25 regulate the activity of the cyclin-dependent kinase Cdc2 that controls entry into mitosis [19].
The IME4 anti-sense transcript causes transcriptional interference, a regulatory mechanism that controls entry into meiosis [67].
We observed a down-regulation in genes that control the entry point into the tricarboxylic acid cycle (Fig. 4).
The medicines work by affecting molecular switches that control the entry of sugar and fat into cells.
It is made up of a 20S catalytic core that is capped by regulatory subunits that control the entry of substrates.
A spokesperson from Teva wrote in an email that the company has "a settlement that controls our entry for which the terms are confidential," while a Gilead representative wrote that "a generic version of Truvada will not be immediately available".
A spokesperson from Teva wrote in an email that the company has "a settlement that controls our entry for which the terms are confidential," while a Gilead representative wrote that "a generic version of Truvada will not be immediately available". Walensky cautions that the availability of a generic form of a drug is not a guarantee of reduced cost.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com