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DOI: http://dx.doi.org/10.7554/eLife.06444.025 10.7554/eLiFigure44.026 Figure 7 figure supplement 1. Spatial firing fields in networks that contain recurrent I → I synapses.
In networks that contain recurrent E → E connectivity, the connections between E cells were modelled as a Gaussian function, that is, similarly to Equation 14: (15) w E → E i j = g E → E exp (− d (i, j, C, e p j ) 2 2 σ E → E 2 ), where C, e p and σE → E have the same meaning as in Equation 11.
Each of the runs was repeated four times for simulations in Figure 2 and three times for simulations in Figure 6D–I and once for networks that contain additional recurrent synapses between E cells or I cells, as well as in networks with synapses generated probabilistically.
In networks that do not contain recurrent E → E connections we set gAMPA = gNMDA = 0 for the E cells, and g GABA A = 0 for I cells.
Another region of frequent hemizygous loss that contains a recurrent homozygous deletion in cell lines is 8p23.
N0 tumors showed repression of modules that contain cell survival genes and in non-recurrent tumors cell-cell signaling and extracellular region modules were repressed.
According to electrophysiological studies in animals with spontaneous recurrent seizures, these are areas that contain groups of pathologically interconnected neurons [ 2, 15, 16].
A subset of recurrent CNAs identified in this study involved regions of the genome that contain known cancer associated genes and were investigated further.
A comparative analysis between the identified sheep CNVRs and those reported in cattle and goat genomes indicated that overlaps between sheep and both other species CNVRs are highly significant (P < 0.0001), suggesting that several chromosome regions might contain recurrent interspecies CNVRs.
Supplements that contain alfalfa.
