Therefore, the NC NC interaction can be considered as an additional parameter (tunable by the NC density) that concurs to the characterization of the system behavior: while the NC-size primarily determines the absorption/emission energy, the interaction level affects the absorption/emission rates.
We and others have previously demonstrated that EGCG can downregulate ER α expression in MCF-7 cells [ 26] and EGFR in MCF-7TAM cells [ 37], events that concur to elicit final apoptosis.
The two-dimensional graphical display of a pathway aims to capture the interdependencies between elements that concur to a biological function resulting from the sequential interaction of the elements.
For example, many lines of evidence argue that autophagy can delay apoptotic cell death upon DNA damage by sustaining the energy demand required to support DNA repair processes, a phenomenon that concurs to the development of chemoresistance mechanisms in cancer cells.
In this context, a critical review of the in vivo tissue engineering results collected so far can elucidate the role of an ECM-like scaffold, to be indented not only as a three-dimensional architecture to accommodate cells, but also as a complex and dynamic mixture of factors that concur to the expected target.
As here demonstrated, dealing with scaffolds structurally similar to the anatomic site to be recovered, like the ones derived from a decellularization process, does not necessarily improve the host response since the key factor is the delicate interplay among different factors that concur to define a specific tissue.
Overall, our results indicate that the Apollon gene silencing causes growth impairment in breast cancer cells carrying a wild-type or mutant p53 gene, mainly as a consequence of apoptosis induction, and identifies p53 stabilisation and caspase-3 activation as major events that concur to determine the apoptotic response.
All these steps require care and knowledge of the manifold branches of science and technology that concur to realise and use the device at best.
In normal wound healing, platelets establish regulatory crosstalks between soluble and cellular actors of tissue repair that concur to the various phases of inflammation and reestablishment of tissue homoeostasis [50, 83, 104, 105].
It is probably that these alterations concurred to the bent phenotype and the motility impairment observed in CD MPO zebrafish.
