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The functional impact scores that measure the deleteriousness of laboratory-induced mutations produced by Condel were quite similar for lab-damaging mutations that completely abolished protein function and the remainder of lab-damaging mutations that exhibited partial protein function (Fig. 3B).
The finding of changes in gene expression and cell death in the CNS specific to notch3 heterozygotes suggests that a partial loss of Notch3 function could contribute to aspects of the pathophysiology of CADASIL that have not been observed in animals that completely lack notch3 function.
Refrigerators and dishwashers can be built into cabinets that completely disguise their function , and some look more like a dresser drawer or a dining room credenza than an appliance.
In order to study the function of ph in follicular epithelial cells of the Drosophila ovary (Figure 1A,B), we used ph504 which is an amorphic allele (noted ph0) with at least two mutations that completely abolish the function of both the ph-p and ph-d units of the ph locus [13].
Despite the efficiency of inserting a mutation that completely disrupts the function of a gene, most genetic factors in common complex diseases are expected to be noncrucial, coding single nucleotide polymorphisms or expression differences [ 55].
Organs can now be supported by machines such as artificial hearts (ventricular assist devices), artificial kidneys (dialysis machines or blood filtration systems), and breathing machines that effectively push oxygen into the blood stream or artificial lungs that completely replace lung function.
If we sort by colors then we will have to go through many categories of other bricks that completely have different functions.
where denotes a scattering function that completely characterizes the WSSUS channel, represents the linearly transformed ambiguity function, and, and equal (4).
Tariquidar, 15 mg·kg-1, a dose that completely blocks P-gp function , was administered as a 15-min infusion 35 min before the second scan to all mice and as a 10-min infusion 20 min before the second scan to all rats, providing optimal inhibition conditions of tariquidar [9].
Thus, a combination of both genetic mutants and RNAi are the C. elegans geneticist's strongest weapon, whilst a technology that completely knocks down gene function in a conditional manner would be ideal.
Loss of function (LoF) variants can be classified as those that completely ablate or decrease protein function , and include nonsense mutations, splice site-disrupting mutations, insertions or deletions that disrupt a transcript's reading frame, or deletions encompassing a large part of protein-coding sequence.
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The phrase "that completely function" aims to act as a relative clause, modifying a noun by describing its functional state. However, it suffers from subject-verb disagreement, as noted by Ludwig. Examples and alternative rephrasing are necessary to achieve grammatical correctness.
Expression frequency: Missing
