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Experimental studies subsequently demonstrated that airway vessels are subject to alloimmune injury and that the loss of a functional microvascular system identifies allografts that cannot be rescued with immunosuppressive therapy.
Ecuador, by contrast, has always been more or less a mess; its plunging currency is only the outward sign of an inward disgrace, of a bankrupt banking system that cannot be rescued by an equally bankrupt government.
In parallel with PC development and progression, these CTL undergo a profound state of peripheral tolerance [29] that cannot be rescued by DC vaccination [29], [30].
By comparison, defects that cannot be rescued by the ssrA-DD allele maybe dependent on the degradation of tagged proteins in wild-type strains, mRNA clearance, or both.
These studies demonstrate that strong suppression of Syx5 causes lethality that cannot be rescued by the manipulation of major copper transporters which mediate uptake and efflux, indicating that intracellular trafficking pathways additional to those involved in copper homeostasis are disrupted.
Gli/EnR would bind to the Gli DNA binding domain and recruit repressors, inhibiting transcription in a fashion that cannot be rescued by other Gli factors, such as Gli1 or Gli3 [65], [65].
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She acknowledged that "the books are dark and scary in places" but "no darkness in Half-Blood Prince...is so immense that it cannot be rescued by a snicker or a smirk".
As previously observed in the evaluation of other CdLS HDAC8 mutants, mutants that are completely inactive cannot be rescued by TM251; mutants that exhibit residual activity can be rescued partially or completely by TM251.
A previous report also found that the ipl1 -2 mutant cannot be rescued by plating on media that slows growth, such as nonfermentable carbon sources (Tatchell et al. 2011).
In contrast, Δ6 displayed a rather low recovery and Δ7 was completely inactive, indicating that the two mutants cannot be rescued by slowing down the folding process (Fig 2D).
This suggests that (i) LVH and cardiac dysfunction cannot be rescued in KI mice at this stage or (ii) that the dose of virus was too low.
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that cannot be obtained
that cannot be eliminated
that cannot be published
that cannot be identified
that cannot be allowed
that cannot be explained
that cannot be taken
that cannot be filled
that cannot be proven
that cannot be updated
that cannot be detected
that cannot be proved
that cannot be ignored
that cannot be made
that cannot be cured
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