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In contrast, the ability to adopt the shifted conformation of stem-loop I is a major determinant of binding: mutants that cannot adopt this conformation bind much more weakly than wild-type and mutants with a constitutively shifted stem-loop I bind much more strongly.
Although the R-state was linked with insulin biological activity, a high activity of an insulin analogue that cannot adopt an R-like fold might indicate that the R-state is not involved in IR binding.
For that reason, Vanhaverbeke & Torremans [ 53] suggested a multidimensional structure, combination of functional and process-oriented structure, with process ownership as a solution for organizations, such as hospitals, that cannot adopt a purely process-oriented structure.
The rationale for this replacement is that a d-Cys for l-Cys substitution makes disulfide bond formation between the adjacent Cys residues much less likely and also results in a very rigid structure that cannot adopt cis amide geometry in the peptide bond between the two Cys residues (ref (37) and unpublished observations of E. L. Ruggles and R. J. Hondal).
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The ECB has made clear that Iceland cannot adopt the euro unless it joins the EU first, which might take years.
For many white middle-class liberals nothing is likely to get them more irate than the suggestion that they cannot adopt a child because the child's race is different from their own.
The Singapore government has always maintained its message of "self-reliance" and stressed that it cannot adopt a welfare-state system.
For Buddhist Epistemologists this mismatch means that they cannot adopt unnuanced the predominant Brahmanical approach of vyākaraṇa, a grammatically oriented metaphysics in which genuine ontological features would be revealed by the features of Sanskrit grammar (such as case and gender accord between adjectives and nouns, connections between substantives via the genitive case, etc.
It's a common misconception that you cannot adopt a specific breed of dog you might be looking for, so you have to find a breeder and purchase them for an outrageous price.
It is concluded that we cannot adopt a single change score to define relevant change by combining the result of previous studies.
However the planar lactam group present in IGL restricts the ring conformation such that it cannot adopt the C 1 conformation resulting in weaker binding due to the longer bonding/interaction distances.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com