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RNAi screening can identify genes that mediate sensitivity or resistance to certain chemotherapeutic drugs and novel drug combinations that can sensitize cancer cells to a chemotherapeutic drug.
Overcoming MDR generally involves multi-modal therapeutic approaches that integrate enhancement of delivery efficiency using targeted nano-platforms as well as strategies that can sensitize cancer cells to drug treatments.
In summary, the present results show that alkylamides evoke a dynamic, multidimensional sensation that can sensitize or desensitize with repeated application.
Generally Nef is viewed as an enhancer of endogenous TCR signaling that can sensitize isolated T cells for activation [7], [8], [9], [10], [11], [12], thereby increasing their permissivity to HIV infection.
Like DEAB, retinoic acid (a vitamin A/retinaldehyde metabolite and product of ALDH activity) appears to decrease ALDH1 and ALDH3 protein levels via a feedback mechanism that can sensitize cells to CPA-induced cytotoxicity [23], [43].
The reactive oxygen species inside the cell can be fatal for R. denitrificans since it is an aerobic anoxygenic bacterium that contains highly absorbing pigments that can sensitize reactive oxygen species formation.
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This study demonstrates that Qct can sensitize cells to TMZ and that the mechanisms of sensitization involve modulation of p53 family members.
The research within the last several years in vitro and in vivo (animal models) showed that curcumin can sensitize cancer cells to different chemotherapeutic agents that are commonly used for Multiple Myeloma treatment.
Allergens that can both sensitize and trigger reactions are known as "complete" allergens; those that can only trigger reactions in previously sensitized individuals are known as "incomplete" allergens.
Some studies have demonstrated that salinomycin is an MDR-1 inhibitor and that it can sensitize cancer cells to other anticancer reagents.
The combined results of previous studies and the present study show that quercetin can sensitize tumor cells to TRAIL by modulating signaling molecules that regulate apoptosis.
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CEO of Professional Science Editing for Scientists @ prosciediting.com