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One such mechanism is the so-called ER overload response that can activate NF-κB activation [ 60, 61].
cGAMP is a strong activator of STING that can activate IRF3 and subsequent type I interferon production.
Nuclear receptor co-regulators are proteins that can activate or repress the transcriptional activity of nuclear receptors.
The urokinase plasminogen activator (uPA) is one factor that can activate latent TGF- β.
PGC-1α is a multifunctional protein that can activate most nuclear receptors and also has a co-activation function for many transcription factors [ 14].
In vitro analysis demonstrated that anti-BMP2 mAbs tethered BMP2 ligands that can activate the BMP receptors on hBMMSCs.
Enhancers are distal regulatory elements that can activate tissue-specific gene expression and are abundant throughout mammalian genomes.
To identify small molecules that can activate p53-responsive transcription, we performed chemical screening using genetically engineered HCT116 reporter cells.
But this rack has a connected lock on it, paired with a social network, that can activate on demand.
Generally, low doses of ROS are served as signals in cells that can activate stress protection mechanisms (Suzuki and Mittler, 2006; Møller and Sweetlove, 2010).
YfiB is an OmpA/Pal-like outer-membrane lipoprotein (Parsons et al., 2006) that can activate YfiN by sequestering YfiR (Malone et al., 2010) in an unknown manner.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com