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A subanalysis of the SUMMIT trial revealed that better response to bortezomib was associated with younger age (response rate 32% in patients aged <65 years vs 19% in those over 65; P<0.05), and with plasma cell infiltration in bone marrow of ≤50%35%5% response rate vs 20% with >50% infiltration; P<0.05) (Richardson et al. 2005b).
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France and Germany especially have suggested that the better response is not more government spending but tighter regulation.
It is possible that the better response in VHL-methylated cell lines might be because VHL-methyation is a marker for other critical epigenetic changes that are reversed by treatment with azacitidine.
Overall, our data strongly indicate that MGMT activity mediates resistance to alkylator therapy and that low MGMT activity is responsible, at least in part, for the better response that accompanies promoter methylation.
The Diamondback has been updated with Razer's third-generation IR sensor that uses five blades instead of four and it's now ensconced in a new non-slip condom material that allows better response time because of its much improved tactile feel.
They pointed out that a better response than cutting emissions would be to dramatically increase research and development on low-carbon energy -- such as solar panels and second-generation biofuels.
It therefore seems preferable to cancel these cycles, in the hope that a better response might be obtained in a subsequent cycle, avoiding in this way financial and emotional implications.
"I realize that these events must be frustrating to many of the trustees and certainly to the college's administration," he wrote, "but suggest that a better response than an alteration of the rules would be to listen to and try to understand the reasoning and motivation of those who keep electing dissident (if that is the right word) trustees".
The Nov. 9 minutes state that "senators expressed need for G.S.O. to convene and rally for Spot, need to raise awareness of location/existence of Spot in grad population, need to raise concerns to administration and petition for the Spot, possibility of doing a new survey of Spot interest that gets better response, need to hold more grad events and non-G.S.O.
It is also clear that a better response plan should've been in place, especially because we're looking at a couple more months before this event is finally over".
We hypothesise that these better response rates may be due to the reduced burden on participants.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com