There could also be experimental effects, such as a difference in recognition and import of native peptides versus the peptide fragments, or regulation in intact leaves that becomes disrupted in protoplasts.
Although the neuronal and microglial changes may be two independent processes occurring in parallel, there is significant evidence of cross-talk between these two populations under homoeostatic conditions that could become disrupted during PD.
16 18 Beyond functional metagenomics, metaproteomic studies will reveal the true expression of metabolic and cellular functions that govern physiology, become disrupted in disease, and can have a profound impact on molecular diagnosis.
It is possible that some of the inflammatory genes altered by parity are also responsive to the development of ER - breast cancer and, therefore, that parity-associated signatures become disrupted with progression of ER - disease.
The oceanic currents that drive hatchling dispersal may become disrupted (Hamann et al., 2011; Van Houtan and Halley, 2011), food availability may be affected (Hawkes et al., 2009) and shifts in latitude may occur as a response to oceanic warming (Witt et al., 2010).
On a more profound level, she mourns the transformation of a patch of the city that, in her eyes, has seemingly overnight become disrupted and ever less neighborly.
