There is a need to develop safer molecules that attenuate tumour progression without adversely affecting the overall quality of life.
We explore factors that attenuate or intensify mesquite expansion, and examine how a series of fine scale, but temporally seminal, events can propagate across multiple scales.
It may be necessary to develop interventions that attenuate these biological mechanisms in order to achieve long-term weight reduction in obese individuals.
Moreover, identification and characterization of these cues should be helpful for designing interventions that attenuate the power of these cues over behavior.
The discovery of candidate drugs that attenuate the effects of unwanted excessive apoptosis will benefit from the knowledge of how after an apoptotic stimulus, cells are able to recover and the molecular mechanisms that use cells to this end.
With subsequent characterization, we successfully identified PHGDH non-NAD+-competing allosteric inhibitors that attenuate its enzyme activity, selectively inhibit de novo serine synthesis in cancer cells, and reduce tumor growth in vivo.
Ecosystem-based coastal protection by means of conserving, restoring or creating intertidal ecosystems that attenuate waves and stabilize shorelines, offers a promising way to climate proof coastlines for the future.
We have designed an STM system based on a mini-Tn10 transposon, chemiluminescent detection and semi-quantitative analysis and have identified transposon insertions into genes of Pasteurella multocida that attenuate virulence in a septicemic mouse model.
Aggregation of the amyloid-β protein (Aβ) plays a pathogenic role in the progression of Alzheimer's disease, and small molecules that attenuate Aβ aggregation have been identified toward a therapeutic strategy that targets the disease's underlying cause.
The structure activity relationship (SAR) of a novel, potent and metabolically stable series of sulfonamide-pyrazoles that attenuate β-amyloid peptide synthesis via γ-secretase inhibition is detailed herein.
However, relatively little is known about negative regulatory mechanisms that attenuate allergic inflammation.
