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In the present study, we have developed 3-alkoxychloroisocoumarins that are potent inhibitors of CEase.
A series of aminothiazoles that are potent inhibitors of LIM kinases 1 and 2 is described.
In this study we report a series of triazine derivatives that are potent inhibitors of PDE4B.
Exploration of the structure activity relationships resulted in compounds that are potent in vitro.
But style trumps words in almost every case here, making for songs that are potent when they're not particularly meaningful.
The Playnice Institute develops and tests games that are potent at counteracting childhood anxiety, the most serious psychological problem facing US families.
The optimisation of the series to give compounds that are potent in an in vivo disease model is discussed.
We have identified a series of novel sulfonamide analogs of (2S,4R -Ketoconazole that are potent inhibitors of these enzymes.
In our effort to develop new farnesyltransferase inhibitors, we have discovered bioavailable aryl tetrahydropyridines that are potent in cell culture.
We describe herein the discovery, synthesis, and optimization of cyclopropyl containing analogs that are potent and selective inhibitors of αvβ3.
Analysis of the 3D structure, activation mechanism, and sensitivity to small molecules had identified several attractive chemical scaffolds that are potent and selective inhibitors of these parasite kinases.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com