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One of them is compiling conjugates of TiO2 or ZnO in their NPs form with monoclonal antibodies, a method that allows targeting the photo- and sonosensitizers on a selected receptor.
Therefore, an approach that allows targeting and selective killing of cancerous MM cells remains highly desirable.
We performed molecular screening using SIFT, a novel method based on single-particle spectroscopy that allows targeting oligomer formation.
RNA interference has been shown to be a powerful tool that allows targeting chimeric oncogenes and gaining a deeper knowledge of tumour biology in its own context (Sharp, 1999; Tijsterman et al, 2002).
Specific benefits of this model system also include the large number of eggs available for study at the earliest of stages (which allowed the discovery of many very early asymmetry-causing mechanisms that have so far been too difficult to study in mice), and a well-defined fate-map that allows targeting of left- and right-side cells at will (which is not possible in zebrafish for example).
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Recently, Siglec-H was also identified as an endocytic receptor that allows targeted delivery of antigens to murine plasmacytoid dendritic cell precursors, which results in the induction of CD8+ T-cells [55].
QuadMAPH is an accurate, high-resolution method that allows targeted screening of large numbers of subjects without the expense of genome-wide approaches.
An animal model that allows targeted, inducible expression of this gene would be useful for studying the mechanisms of ALL initiation and progression in vivo.
For those who wish to examine copy number variation of a defined region(s) (of, for example, 100-200 kb) our four vector systems, combined with QuadMAPH, constitute an accurate, high-resolution method that allows targeted screening of large numbers of subjects without the expense of genome-wide approaches.
At John Hunter Hospital, a teaching and referral institution, MIP is performed either through a 20-30 mm incision and open technique, that allows targeted removal of a preoperative localized adenoma, or through a 15-20 mm incision and video-assisted technique [ 5, 8].
Engineering systems that allow targeting cells, tissues or other biological structures of interest may provide a way to modulate local pharmacokinetics of promising microbicide molecules and, thus, maximize protection.
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