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While there are no comparable data to show that adherence with once-daily is better than twice-daily DOAC therapy, adherence with once-daily cardiovascular medications are typically better than twice-daily medications [ 62].
A limitation of our study was that adherence with the intervention was incomplete.
There is no doubt that adherence with guidelines is associated with better outcomes.
It has been shown that adherence with the gluten-free diet is important for obtaining similar HRQoL among children with celiac disease as their peers [ 39].
Indeed, it is well known that adherence with these guidelines depends on many other factors [ 9- 11] such as guideline, professional, patient and environmental characteristics.
Although adherence rates in the study were less than prescribed, it was found that adherence with once-daily treatment was superior to adherence with twice-daily treatment.
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One reason is that adherence is lower with behavioral interventions than with pill-taking [ 6] and adherence may contribute to the effectiveness of the intervention.
Our study confirms prior literature reviews which highlighted that adherence to and persistence with traditional and biologic DMARDs among patients with RA are suboptimal [ 20– 23].
That is in contrast to large quantitative studies that describe adherence with medications to be around 50-70% [ 43- 45].
Given that poor adherence with self-management medication is very common among asthma and COPD patients, interventions that improve the use of chronic disease management medications for this patient group have potential to generate positive health outcomes.
To identify variables that predict adherence with annual eye examinations using the Compliance with Annual Diabetic Eye Exams Survey (CADEES), a new questionnaire designed to measure health beliefs related to diabetic retinopathy and annual eye examinations.
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