Studies of mutational composition of individual cells showed that accumulation of mutations within a cell usually does not occur via accrual of random hits.
25 In Part I, it was found that accumulation of DCs within glioma and peritumoral area was associated with longer survival as compared with GCLRP-treated animals where PMs predominated.
It is believed that accumulation of α-syn within intracellular inclusions is the primary event in Lewy body formation.
It is highly likely that accumulation of ESAT-6 within mycobacterial cells may be toxic.
Subsequent studies demonstrated that accumulation of unfolded proteins within the mitochondrial matrix results in the induction of mitochondria-specific HSPs, a process referred to as the mitochondrial-unfolded response (mtUPR) [ 58].
In our study, we showed that accumulation of amplification occurring within exclusively amplified genomic regions is related with relapse-free survival whereas genomic clones prone to random chromosomal aberrations blurred the impact of copy gains on survival.
First, accumulation of hnRNP-K within the nucleus of ASFV infected cells was evident and subsequently the levels of cytoplasmic hnRNP-K decreased while nuclear levels were increased, as infection proceeded, supporting the idea that accumulation of hnRNP-K within nucleus is most likely due to relocation from cytoplasm.
The epilepsy prevalence in this selected family was estimated at 33%% [ 41], which showed that accumulation of epileptic individuals within certain breeding lines can result in substantially higher prevalence estimates than in the breed in general (as reflected by the two Danish studies) [ 23].
There is also accumulating evidence that iron accumulation within neurons contributes to the development of several common neurodegenerative diseases, such as the Alzheimer's, Parkinson's and Huntington's diseases (Berg and Youdim 2006; Sipe et al. 2002).
Because myelin facilitates conduction, we speculate that AGE accumulation within myelin may interfere with conduction.
