Sentence examples for that I rigged from inspiring English sources

It's been an unusual decade; I spent much of it hunched over spiral notebooks and laptop computers in libraries and cafés and at kitchen tables here and in France while writing a book (remind me to mention the bathroom, in a house in Normandy, that I rigged out as a nocturnal study), and didn't maintain my usual diet of cinephilic delights.

What is crucial to notice here is that you prefer that I rig up the alarm, since this makes your promise to give me my share credible.

The dumbbell was unable to induce signaling by wild type RIG-I, demonstrating that RIG-I cannot signal from an exclusively internal binding site.

What he didn't realise is that I had rigged up a magic trick that would sound like someone knocking on his bedroom wall.

The IFN-β stimulation from the 5′ppp10L construct is of particular interest because it strongly supports the idea that RIG-I does not survey the cell as an oligomer, that RIG-I does not need to oligomerize on a target RNA duplex strand to elicit an IFN-β response, and that RIG-I does not need to translocate on duplex RNA regions to elicit an IFN-β response.

This is consistent with our SV analysis, and taken together, these results show that RIG-I specifically recognizes the base-paired terminus of duplex RNA, and that RIG-I does not form protein protein-mediated oligomers even in the protein protein-mediated/ATP analoligomershown in Luo evenl [ 29]).

To understand the conformational changes that RIG-I undergoes during RNA recognition and surveillance, we visualized the conformations of RIG-I (ΔCARDs: 1 229) in complex with 5′OH-GC10 (Fig 1A; supplementary Table S1 online), which show well-ordered scanning movements of the HEL2i domain along the duplex RNA backbone.

In support of our evidence that RIG-I is not the PRR used to detect hantaviruses, recent work has shown that RIG-I recognizes RNAs with 5' triphosphate groups [40].

We would of course like to confirm that RIG-I also senses dsRNA without 5' tri-phosphate ends, by examining whether capped GFP dsRNA (from SeV infected cells) activates IFNβ upon transfection.

Thus, an intriguing possibility is that RIG-I family genes in C. elegans initiate RNAi rather than the interferon response.

Notably, they found that this ubiquitination is unique in that RIG-I associates with free unanchored K63-linked ubiquitin chains that are catalysed by TRIM25.