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A search strategy was finalized utilizing MESH terms, Boolean terminology, and free text terms (Additional file 1: Annexure 1).
Text terms such as 'stimulates' or 'activates' usually led to inclusion of a stimulation link.
Text terms such as 'inhibits' or 'represses' or 'marks for degradation' usually led to inclusion of an inhibition link.
More specifically, the text terms 'activates', 'stimulates', 'inhibits' and 'represses' led to inclusion, when the term included the adverb 'directly'; otherwise they were investigated further.
For example, text terms such as 'interacts with', 'binds to' or 'forms a complex with' usually led to inclusion of an interaction link.
We used free text terms only in The Cochrane library.
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The search was conducted using free-text terms and standardised subject terms appropriate to the specific database.
These terms were used as free-text terms (translated into Chinese) to search some of the Chinese databases.
In CENTRAL, only free-text terms were applied.
In the latter, the MeSH terms are expanded with free-text terms.
The search strategy in the other three databases only included the free-text terms.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com