As per the reviewer's suggestion, more details of sequence selection criteria are now incorporated in text (methodology section, first paragraph).
The contents of the non molecular data file can also be utilized by further subjecting it to standard text mining methodologies [29, 30] for retrieving molecule names or other information such as list of basis sets employed in the specific computational work.
This enables structure-based chemical informatics techniques such as substructure search and molecular similarity to be added to the repertoire of text mining methodologies, increasing the range of information that can be extracted, and the range of analyses that can be performed.
Rather than focusing on the individual miRNA-target interactions, pathway analysis and text mining methodologies were used to understand the biological functions and processes in pain.
The study demonstrated that text mining methodologies such as topic modeling provide an alternative method compared to traditional means for data reduction in toxicogenomics, enhancing researchers' capabilities to interpret biological information.
The whole BioCreative experience highlighted that in order to obtain substantial advances in the development of text-mining methodologies, it is necessary to develop close collaboration among different communities: text miners, database curators and ontology developers.
Figure 1 An overview of the text mining methodology.
Using a novel text analysis methodology, we transform analysts' qualitative statements into a content-based text signal.
The method was successfully validated according to the USP<1225> Validation of Compendial Procedures and International Conference on Harmonization (ICH) guidelines Q2 (R1) for validation of analytical procedures: text and methodology [10, 11].
s corresponds to the standard deviation of the intercept and b to the slope of the linear regression plot (International Conference on Harmonization of Technical Requirements for Registration of pharmaceuticals for Human Use: Validation on Analytical Procedures, Text and Methodology, Q2(R19961996).
