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Statistical analysis Comparisons between treatment groups were calculated with t tests or Wilcoxon rank-sum tests when appropriate.
Statistical analysis Mixed model ANOVA was performed on raw or transformed data, followed by Tukey HSD post hoc tests (when appropriate).
For data that was not normally distributed, Friedman's nonparametric two-way analysis of variance was used, followed by the Wilcoxon signed rank tests when appropriate.
Age, sex and smoking were adjusted in all the tests when appropriate.
We analyzed results using chi-square tests and Fisher's exact tests when appropriate.
We compare the fit of random models to the SR, ECM, LCAP, GA and REV models using <img src="http://journals.plos.org/plosone/article/asset?id=info?doi/10.1371/journal.pone.0011587.e042.PNG" class= inline-graphic"/> scores and likelihood ratio tests (when appropriate).
We used non-parametric Mann–Whitney U tests when appropriate.
Chi-square tests (or Fisher's exact tests when appropriate), as well as t-tests (or Mann-Whitney tests when appropriate) were used to compare qualitative or quantitative data.
Differences were tested using the χ or Fisher's exact tests when appropriate.
Univariate ANOVA with Tukey's posthoc tests, when appropriate, were performed using PASW-17 software.
Categorical variables were compared using the Chi square and the Fisher's exact tests when appropriate.
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