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Tests of trend were also performed across HbA1c quartiles.
We did tests of trend using continuous dose in defined daily doses for each class.
Tests of trend in relative risk across tertiles used the Jonckheere-Terpstra test [ 14].
None of the tests of trend across exposure categories was significant (p > 0.05) (data not shown).
The gradient depicted highly significant p-values for tests of trend in both sexes (Table 3).
Ptrend and Phet are P-values for the tests of trend (1 df) and heterogeneity (3 df) respectively between quartiles.
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The Cox proportional hazards regression model was also applied over multivariate analyses, with the associated likelihood ratio test used to assess test-of-trend differences.
Homogeneity tests of trends neither between ER− and ER+ nor between HER2− vs. HER2+ was statistically significant (both Phomogeneity of trends ≥ 0.19).
Tests of trends in hormones across levels of migration history were obtained by scoring the categories and considering it a continuous variable in standard regression models.
§Result of Pearson Chi-squared Test for binary predictors, result of Cochran-Armitage test of trend for variables with more than two levels.
The most powerful test of trend dynamics is one involving direct comparisons of large numbers of ancestor descendant pairs (Fig. 10; McShea 1993; Alroy 2000; Wang 2005).
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