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On this Friday morning, a steady parade of infected patients came in for tests of liver function, viral load and white blood cell counts.
Last summer, the food and drug agency required that the labeling be changed to say that Rezulin should be used only in patients for whom other treatments had failed, and that they should have monthly tests of liver function.
Biochemical tests of liver function including alanine aminotransferase, aspartate aminotransferase, and gamma-glutamyl transpeptidase and the erythrocyte sedimentation rate were elevated for a mean 17 +/- 22 months before vancomycin treatment was initiated.
But Dr. Anne Peters, an endocrinologist at the University of California at Los Angeles who was among those who tested the drug in patients before it was approved, said that problems with Rezulin were apparent in testing and that it should have been marketed with strong warnings and a requirement that patients have frequent tests of liver function.
Blood tests of liver function in patients with cholangiocarcinoma often reveal a so-called "obstructive picture," with elevated bilirubin, alkaline phosphatase, and gamma glutamyl transferase levels, and relatively normal transaminase levels.
No significant correlation could be demonstrated in individual patients between the serum CEA concentration and various tests of liver function.
Similar(44)
> There were no significant abnormalities between groups in terms of liver function tests and fasting lipid values.
Hematology, blood chemistry tests consisting of liver function tests, thyroid function tests, blood urea nitrogen, creatine, electrolytes, vitamin B12, folic acid, and ferritin were performed at the initial screening to evaluate secondary reasons of headache.
In adult liver recipients, a more sensitive test of liver function, the LiMAx test, could predict tacrolimus trough levels [ 41].
Fourteen of these 39 individuals (8 of 14 were females) had at least one abnormal test of liver function.
This circumstance is, in fact, used in Quick's well known test of liver function [ 14, 18].
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