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Gene-wide tests of significance also provide a useful framework for dealing with the vast number of tests inherent in genome-wide association [ 22].
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Their statistical significance is tested while adjusting for the multiple testing inherent in such a procedure.
Similarly to Satscan, inference analysis has to avoid multiple testing inherent to such a procedure.
The FDR method accounts for the multiple hypothesis testing inherent in the TSP algorithm.
Substantial samples are also required to offset the enormous degree of multiple testing inherent in genome-wide studies.
However, when calculating significance one should correct for the multiple testing inherent when many spatial locations are evaluated.
We used permutation to correct for the multiple testing inherent in examination of multiple microsatellite alleles as instituted in the program CLUMP.
The FDR represents an expectation of the proportion of false positives among the selected differentially expressed genes, which increases dramatically during multiple testing, inherent in microarray experiments[ 12].
Each cylinder represents a candidate area and duration for a true disease outbreak, and the method adjusts for the multiple testing inherent in the many cylinders evaluated.
By providing a comprehensive list of associations from NHANES, the relative strength of association can be considered rather than attempting to interpret p-values in light of the extensive multiple testing inherent with this data set (Sobus et al. 2015).
While this latter approach is flexible in haplotype construction, it is limited to transmission statistics in the FBAT software (Horvath et al., 2001) and lacks a valid significance assessment that accounts for all the multiple testing inherent in a data-mining technique.
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