Moreover, using a macaque model allowed us to re-challenge a subset of the macaques after completion of PrEP to directly test for protective effects of immune responses.
Testing for protective sensory threshold is done with a Semmes Weinstein 5.07/10 gm monofilament (Semmes Weinstein Corp., NY, USA).
A high-throughput screen of chemical libraries identified several lead compounds that increase Klotho expression and will be tested for protective effects against Aβ-induced pathology.
Tal6 was also tested for protective activities in analogy to the experiments performed with other LysM effector proteins but these were not detected.
In testing for protective ability of mutated strains, birds were first given an immunizing dose of G9Δ crp (same dose as above) and then challenged with the same dose of wild type G9 ten days post immunization.
Research-grade 2-, 4-, 6-, 8-, 10-, and 15-g monofilaments (Bailey Instruments, Manchester, U.K). and 128-MHz tuning forks were used to test for protective sensation in subjects with eyes closed (5) (see Clinical Protocol available in the online appendix).
Finally, cytokine-blocking antibodies (Ab) were added to the sera to analyze the respective involvement of the cytokines in the stiffening effects of the patients' sera and to test for protective effects against the pathological stiffening effects of the patients' sera.
In testing microbicides for protective efficacy in a mouse chlamydia model [ 23], we found that chlorhexidine (CHX), a widely used microbicidal preservative, causes a 100-fold increase in vaginal susceptibility to Chlamydia trachomatis when tested three days after a single vaginal application of this surface-active agent.
In order to determine the relevance of the few differences found between peptides regarding their protective capabilities, full sequences of GK1 and KETc1 and their respective truncated versions were tested for their protective capacity using a murine model of cysticercosis, which has been extensively employed to identify antigens of interest for vaccination.
HBV envelope contains three surface antigens, called pre-S1, pre-S2 and S. For the prophylaxis of HBV infection, only an anti-S monoclonal antibody was tested for the protective efficacy against HBV infection, but it was shown to be incomplete.
