Each pool was tested for activity on mechanically activated currents expressed by DRG neurons.
Using KINOMEscan (Ambit Biosciences, San Diego, CA, USA), Nec-1 (10 μM) was tested for activity against 485 kinases and activated mutant kinases.
We have also detected potential 'quick wins' through the identification of targets for repurposing known drugs or active chemical tool compounds that can be tested for activity in cancer models.
After the reaction is completed, the chambers are individually tested for activity.
These monolithic biocatalysts were tested for activity and stability and compared to similarly prepared biocatalysts employing classical cordierite ceramic monoliths.
Platinum catalysts (1.5 wt.%) containing AlSBA-15 obtained with various aluminium precursors were tested for activity in 1-methylnaphthalene hydrogenation.
Based on the essential structural requirements predicted by the QSAR models, some analogues were designed, synthesized and tested for activity.
A series of 1,3,4-oxadiazol-2-ones 1,3,4-oxadiazol-2-ones 1,3,4-oxadiazol-2-ones 1,3,4-oxadiazol-2-onesellular beta-arrestin redistribution assays.
Eventually, the best (ADMET and pharmacophore score) candidate structures will be proposed for synthesis and tested for activity.
Seven classical alkylators were tested for activity against the continuous human medulloblastoma cell line TE-671 grown in vitro and as s.c. and intracranial xenografts in athymic mice.
