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In CIA and AIA model tests, compound 6 exhibited similar efficacy to tofacitinib citrate.
Then in the following tests, compound 65 was treated respectively with ethyl bromide, allyl bromide, bromoactylacetone, and diethyl malonate bromide by molar ratio of 1 3, and afforded a series of quinazoline derivatives via S-monoalkylation.
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Each test compound was conducted in triplicate.
Toluene was used as the test compound.
The thrombolytic ability of the test compound is evaluated.
Tubes without any test compound were used as a control.
The test compound is injected prior to the thrombus formation.
The cell cytotoxic effect of each tested compound was calculated.
Test compound was replaced by DMSO (7.5% final) as control.
The test compound was dissolved in DMF (1 mg l−1).
This would indicate the anticoagulant nature of the test compound.
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