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Compared to a single molecule or reaction, a feedback loop is an easier target for testing therapy schemes.
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A clinical trial testing therapies for advanced tongue and tonsil cancers has found that more than 40percentt of the tumors in men were infected with HPV.
Steinman also pushed hard for testing therapies in people.
Recent studies cast doubt on the value of traditionally used models as tools for testing therapies for human cancer.
It will therefore be of great therapeutic importance to identify possible initiating factors in BD also by testing therapy-naïve patients.
However, clinical trials testing therapies against FOLR1 in ovarian carcinoma have produced mixed results.
In particular, they may be useful for testing therapies that induce apoptosis through Trp53-independent pathways.
In addition, with limited resources including time and funding, scientists are cautious about testing therapies where the preliminary data are limited and not very encouraging.
CFTR-F508 pigs provide a relevant model to further investigate mechanisms of CF pathogenesis and for testing therapies that aim to increase CFTR activity.
Costs and characteristics of diagnostic tests, therapy, patients' quality of life and associated costs were respected.
The marked heterogeneity of the patient population and small signal (tested therapy)–to-noise (comorbidities) ratio makes identification of treatment effect difficult.
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