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In a predefined trial with subgroup testing the trial should be powered such that the expected effect, if present, should be detected in the smallest subgroup.
This feasibility study is testing the trial procedures in preparation for a main trial; if we demonstrate clinically important adjuvant effects of auricular acupuncture to our exercise programme, this will provide the rationale for a fully powered trial.
The sequential analysis confirmed the primary meta-analysis when using the traditional 5% level of statistical significance (figure 3), but not after adjusting for multiple testing (the trial monitoring boundary was not crossed).
The dialysis prescription, pre- and post-dialysis blood pressure and weight data collection, the salt sensitivity testing, the trial intervention compliance checked, and the serious and non-serious adverse event reviews were completed at each interview.
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The trial was testing the drug in patients whose anemia was caused by the cancer itself, not by chemotherapy.
Clinical trials testing the value of antioxidants in treating Alzheimer's are under way.
The agency said Friday that it was aware of other trials testing the potential neurological effects of epoetin alfa.
The majority of measures tested in the trial proved suitable.
A detailed manual, which was pilot tested before the trial, chronologically described the case managers' duties.
Recalling the Judea, the bark on which he served as second mate, Marlow says that, to him, it was not "an old rattle-trap" but "the endeavour, the test, the trial of life".
In addition to putting Celebrex to the test, the trial could have significant implications for the other two medications.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com