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As siRNA therapy advances into clinical testing, the risk of unexpected side effects needs to be studied very carefully, he says.
This early detection, which has not been shown to have a significant impact on mortality, comes at the price of additional testing, the risk of overtreatment and downstream adverse effects, and impaired quality of life that currently cannot be precisely quantified.
The increased risk of death associated with bloodstream infection interacted significantly with neutropenia and immunosuppressant exposure; compared to patients without blood culture testing, the risk of death with bloodstream infection was extensively and significantly higher in patients who were neutropenic and those exposed to immunosuppressants.
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Survival curves were produced using the Cox proportional hazards model to test the risk of cancer death.
To determine the safety of introducing ERBB4 into MSCs, we tested the risk of malignant transformation.
We tested the risk of multicollinearity by studying the variance inflation factor [ 28].
With the highest doses tested, the risk of headache was increased compared with placebo.
At both doses of cladribine tested, the risk of 3-month CDP was approximately 50%% lower than with placebo (p < 0.05, both) [ 39].
For each window of varying position and size, the software tested the risk of HGE within and outside the window, with the null hypothesis of equal risk.
For each window of varying position and size, the software tested the risk of HFRS within and outside the window, with the null hypothesis of equal risk.
When multiple hypotheses are tested, the risk of false positive conclusions can increase and be higher than the intended level of e.g. 0.05.
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