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For many genes, we simply do not know enough about the function of the gene-product and therefore lack methods for testing the consequence of sequence variation, especially in high-throughput fashion.
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Specifically, as we have provided backing for the Generalization, Extrapolation, and Utilization inferences, we should in the future examine other areas related to the Domain representation, Evaluation, Explanation, and Extrapolation inferences, as well as testing the consequences in the Utilization inference (see Xi, 2010, for specific questions to be examined).
This called for testing the consequences of loss of N-AChE-S function on apoptosis.
Given the availability of drugs like lamivudine, we can also immediately begin testing the consequences of inhibiting L1 reverse transcriptase, both in cell culture and in the mouse.
Testing the consequences of changes in quantity and composition of the uropygial gland secretions for regulation of feather bacterial communities is thus an important path for future research about bird-microorganisms interactions.
One can also distort a signal in unnatural but useful ways, as with testing the consequences of asynchrony between acoustic and visual courtship components when a living animal is incapable of such behavior.
Next, we tested the consequence of the potentially weak intercellular communication in the absence of light.
Hence, we used a conditional pan-neuronal driver (ELAV-GeneSwitch) to test the consequence of neuronal CycD/Cdk4 overexpression.
To examine this directly, we tested the consequence of XCT 790 exposure on mitochondrial respiratory potential through measurements of oxygen consumption and extracellular acidification.
To test the consequence of the XRCC4 mutation on DNA repair efficiency, wt and mutant fibroblasts were first exposed to γ-rays (0.5 Gy), in order to induce DNA DSBs.
DOI: http://dx.doi.org/10.7554/eLife.06132.042 Given the evidence of erlotinib-mediated FOXO activation and its potential regulation of SOX2, we tested the consequence of siRNA-mediated knockdown of each gene family member, alone and in combination.
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