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The Bonferroni-Holm method was used to correct for multiple testing of the secondary endpoints presented in Table 3.
The intent-to-treat (ITT) population consisted of randomized patients with baseline measurements and at least one postbaseline measurement of weight and HbA1c taken after randomization and was the main population for the superiority testing of the secondary endpoints.
Under the CTP, if the null hypothesis for the primary endpoint (OS) is rejected at the 1-sided significance level of 0.025, then testing of the secondary endpoints will proceed in a sequential step-down manner and a 1-sided significance level of 0.025 will be used at each testing step.
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Approaches to secondary-electrode formation, traction force testing, novel microprobe formation in batch mode, work capacitance, and pulse current effects, insertion durability tests, and life expectancy tests of the secondary-electrode are all evaluated in detail.
Hypothesis testing of the main secondary variable was to follow the primary analysis if the primary null hypothesis was rejected.
Since the relevant primary null hypotheses were not rejected, no testing of the gated secondary objectives was needed.
Only when the null hypotheses from the primary testing sequence were rejected, would testing of the gated secondary hypotheses have commenced using a parametric gatekeeping procedure: test the efficacy of LY2140023 treatment versus placebo in the overall population, followed by testing in the predefined subpopulation.
Testing of the key secondary end point occurred only when both active doses were superior to placebo on the primary end point to control the study-wise type I error rate across the primary and the key secondary end point of CGI-I, as well as across the 2 active dose arms.
To determine the prevalence of routine parathyroid hormone (PTH) testing as part of the secondary osteoporosis screen in an inpatient ortho-geriatric population, and the incidence of diagnosing primary hyperparathyroidism (PHPT).
Laboratory evaluation of bleeding disorders includes testing for defects of the secondary hemostasis (prothrombin time and activated partial thromboplastin time), which will not be discussed in the present article.
In the literature, material properties are typically only available in the longitudinal direction, and most international standards do not provide details on the testing of the other two secondary directions (radial and tangential).
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