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We reasoned that testing of the overlap between these upregulated genes and GWAS risk loci for inflammatory disease would identify genes of importance for intestinal immune homeostasis potentially subject to transcriptional regulation modulated by disease-associated genetic variation.
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In doing so, this work will also bring experimental tests of the overlap between quantum and relativistic regimes closer to realisation.
The number of genes differentially expressed in each cell line, with respect to both other cell lines, but not in the other cell lines with respect to each other; the number of genes within 20 kb of a cell-line specific CTCF binding site; and the p-values from Fisher's exact test of the overlaps between those sets.
Not all cytobands genetically linked to AE have been discovered, which might increase the pre-test probability of the overlap and decrease the significance of the above findings.
We used the hypergeometric test to test the significance of the overlap between each signature and gene set.
The hypergeometric test was employed to test the significance of the overlap between each signature and gene set.
Through statistical testing, the significance of the overlap can be assessed.
To test the significance of the overlap with intergenic eCGIs, we applied the χ test, considering only autosomal chromosomes and assuming 0.89 as the mappable fraction of the genome.
Applying the spatial overlap testing method, the overlap of the FTLD co-ordinates with the FES spatial map generated by ALE was significant (p = 0.001).
Associations between physician specialty and continuous dependent variables were tested by means of the overlap of confidence intervals for the estimates of each specialty group.
In this work, we applied the widely used hyper geometric cumulative distribution function to test the significance of the overlap: Where x stands for the size of intersection set; K represents the number of the candidate genes; N stands for the number of the genes in the pathway; and M represents the number of all genes in our calculation (the universal gene set).
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CEO of Professional Science Editing for Scientists @ prosciediting.com