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This new procedure takes only 3 h, and it can be used for parallel testing of multiple samples.
Testing of multiple samples by xpert detected only two additional cases and the benefits must be considered against costs in each setting.
Testing of multiple samples did not increase case detection for MODS and testing of a second sputum sample by Xpert detected only an additional two cases.
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Twelve studies tested samples of only one type, whereas the remaining fifteen studies reported on testing of multiple sample types.
Robust standards were used to adjust for possible dependence of multiple samples from the same patient or test results of different tests on the same sample.
The comparison between two of multiple samples were analyzed using the LSD and SNK tests.
Analysis of variance followed by the nonparametric test of multiple independent samples was used to assess the significant differences of multiple samples and a value of P < 0.05 is considered statistically significant.
Comparison of multiple samples was performed by ANOVA followed by Student Newman Keuls post hoc testing.
T2C also allows multiplexing of samples for the direct comparison of multiple samples.
Statistical significant differences were determined between the samples using ANOVA (analysis of variance; f-test for multiple samples or two samples with α = 0.05); and Fishers least significance tests.
Conversely, the testing of multiple blood samples, as part of a screening strategy, increases sensitivity sufficiently, such that consistently negative tests results exclude disease.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com