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Schork et al. [52] state that statistical testing of collections of rare variants, as a group, is a new but "crucial" development in genetic epidemiology.
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Instead we have completed our initial test of Collections and are now analyzing the data to inform product development.
To ensure that the data will be collected in a standardized way in all the participating clinics, a pilot testing of data collection and data management will be conducted prior to the start of the baseline data collection.
A subset of the model parameters are described as correlated random variables to represent the significant unit-to-unit variability observed during testing of a collection of the switches.
Here we present the design, synthesis and testing of a collection of three caged compounds: anisomycin caged with a diethylaminocoumarin moiety and dimethoxynitrobenzyl caged versions of 4E-BP and rapamycin.
Some of the testing would be relevant for any intervention trial (eg. testing of data collection instruments or training manuals) and not just those involving a complex intervention.
Specific areas to be reviewed included the integrity of the study protocol, testing of data collection forma and acceptability of the intervention.
As suggested by Lancaster (2004) [ 9] and Arain (2010) [ 10], specific areas to be reviewed included the integrity of the study protocol, testing of data collection forma and acceptability of the intervention.
Moreover the second pilot study has been useful to test procedures of collection and bio-banking of biological samples that are scheduled at the end of 2010.
If there are variants that confer protection as well as risk, both will tend to be included, but this is a fundamental problem of testing a collection of rare variants.
First, having been able to explain the rebound in observed case notifications as a function of testing volume, collection of more detailed data could highlight contextual epidemiological differences among those being tested for chlamydia.
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