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Plan do study act (PDSA) cycles provide a structure for iterative testing of changes to improve quality of systems.
If the objective is to improve care in patients with progressive multiple sclerosis, then iterative testing of changes, and learning from these tests, may be more valuable than testing the effectiveness of a "set intervention".
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Neither is further statistical testing of change or trends appropriate given the variation in facilities sampled and sampling approaches.
Application of PDSA cycles was assessed against key features of the method, including documentation characteristics, use of iterative cycles, prediction-based testing of change, initial small-scale testing and use of data over time.
This is similar to tests of changes in model R2 in a typical ANOVA or regression.
This configuration allows for closer contact between the filter additive (CR20) and the triactein plasticiser of the cellulose acetate filter, and is therefore a more rigorous test of changes in the adsorption efficiency over time.
The change between baseline and 28 weeks' gestation in the percentage of women with any problem was assessed using McNemar's test of changes.
For the EuroQoL subscales, the overall change over time is estimated as a risk difference, by McNemar's test of changes.
Formal statistical testing (χ test) of changes in performance between visit 1 and visit 2 in each group did not reveal significant differences.
We chose to perform an omnibus test of changes in expression across life cycle stages simultaneously because of the large number of life cycle stages and their complex developmental dependencies.
Multiple small-scale tests of change are integral to changing practice in a high-risk environment.
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