Exact(12)
Clinical testing of agents that increase metastasis-suppressor gene expression is expected to require tailored trial designs.
Additionally, NINDS supports pilot clinical trials that focus on the timely and efficient testing of agents to determine if resource-intensive comparative efficacy trials are warranted.
CONCLUSIONS: There is a need for improved experimental design, execution, and reporting of preclinical testing of agents that are candidates for clinical use in combination with radiation.
These data demonstrate that the PEL/SCID mouse is an important preclinical model to characterize efficacy and anti-tumor mechanisms of new therapeutic targets in vivo and will be useful in the design and testing of agents in viral lymphoproliferative diseases.
The clinical success of bevacizumab has bolstered the development and testing of agents that directly target VEGF, selectively inhibit VEGFR1 or VEGFR2, or promiscuously block both VEGF receptors as well as other receptor tyrosine kinases [12], [13].
The ability to manipulate tumoral androgens will be critical in the development and testing of agents targeting CRPC through tissue steroidogenesis.
Similar(48)
But even for budget travelers, the overall experience can offer better value, as my colleague Seth Kugel found in a recent test of agents versus online search engines.
In order to facilitate different precipitation mechanisms in dentinal tubules [ 9, 24] during effectiveness tests of agents resolving DH, a liquid medium similar to dentinal fluid has some advantages in a dentine perfusion assay.
Some antiangiogenic agents were even completely devoid of toxicity, and defining an optimal dose for subsequent activity testing of these agents was difficult, if not impossible.
It is likely that clinical testing of these agents will be in combination with standard therapies to harness the apoptotic potential of both the agents.
But he said the tapes, as described, were consistent with what intelligence analysts have said about Al Qaeda's quest for chemical and other weapons of mass destruction and its testing of "crude" agents.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com