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Archival data are an underused resource one that can highlight processes and be useful in testing lifespan models.
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After the last behavioral test, lifespan was determined.
Therefore, we tested lifespan and motor activity of adult repo-Gal4/ UAS-hHtt103Q (repo; hHtt103Q) flies, and found lifespan shortening and abnormal motor activities (Fig. 2A, B).
Given the close relationship between aging and stress tolerance, we tested lifespan and found that PTL-1 and SKN-1 regulate longevity via similar processes.
After adjusting for multiple testing, the lifespan of mutant mated males was not different from the lifespan of control males and males with all four reversions (Table 1, Figure 3H).
Next, we tested the lifespan of each enhancer trap line, selecting ten in which longevity was extended by >30% in both sexes.
We therefore tested the lifespan phenotype of mir-71; daf-16 double null mutants.
Based on our large data set of survival records, we tested whether lifespan extension correlates with lifespan of the control.
In contrast, BB polyphenols had no effect on bacterial population growth at the doses tested in lifespan assays (Fig. 6A).
We also tested the lifespan of all four haploid progeny of one tetrad and found consistent co-segregation of the deletion allele of afo1 with extended lifespan.
Log-rank tests showed lifespan was significantly longer for hNAG-1 mice than for WT mice in both lines with both diets.
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