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Extreme genetic heterogeneity along with remarkable variation in the distribution of causative variants across in different ethnicities makes single gene testing inefficient for hearing loss.
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Regarding these observations, the tests inefficient to control the false-positive rate at the expected <img src="http://journals.plos.org/plosone/article/asset?id=info?doi/10.1371/journal.pone.0012336.e158.PNG" class= inline-graphic"/> level have to be adjusted by a time consuming Monte-Carlo procedure.
When applied to symptomatic patients with a negative initial ultrasound result, serial testing is inefficient and not cost effective.
HIV-infected patients show reduced delayed hypersensitivity skin test reactions and inefficient responses to common vaccines [15], [16].
These experiments confirmed that, for the genes tested, the Fe inefficient plants had higher levels of gene expression than Fe efficient plants (Table 3 and[ 16]).
The following existing automatic annotation transfer tools were tested and deemed inefficient: (i) GATU, dedicated to viral genomes [ 88], and (ii) RATT, based on synteny conservation, which only applies to closely related genomes [ 89].
To test whether the inefficient cleavage of METΔ7 8 in E98 cells is related to intracellular transport defects, we analyzed the subcellular localization of METΔ7 8 in detail via confocal microscopy.
Unfortunately, in many cases this test in inefficient.
As the number of space dimensions increases, the tests become inefficient [26].
Strategies with high sensitivity will correctly identify most individuals at high risk, but they will lead to unnecessary diagnostic tests and inefficient use of scarce preventive resources.
However, the sensitivity of VI testing varies between laboratories due to inefficient viral growth in cell culture and lack of cytopathic effect.
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